Cryo-electron microscopy has been established as a method to enable observation of cells and biological molecules with no fixation and no staining. Owing to the recent rapid progress of hardware and software, this microscopy technique has become increasingly important as an atomic-scale structural analysis method. In addition, technologies that enable analysis of membrane proteins without crystallization have been developed, resulting in increased use of cryo-electron microscopy for drug discovery. Thus, installation of cryo-electron microscopes (cryo-EM) in universities and research laboratories is greatly accelerating. To meet the needs of cryo-EM users, JEOL has developed a new cryo-EM “CRYO ARM™ 200 II”, which automatically acquires image data for Single Particle Analysis over a long period of time.
Cold field emission gun (Cold FEG)
In-column Omega energy filter
Maximum specimen tilt angle
※ Schottky field emission gun can optionally be configured.
Specimen cooling temperature
100K or less
Temperature measurement position
Specimen, Cryo-shield, LN2 tank
Motor drive (movements: ±1 mm)
Motor drive (movements: ±0.2 mm)
Motor drive (tilts: ±70°)
Rotation within the specimen plane
0° or 90°
Specimen exchange system
105K or less
Specimen exchange cartridge
Up to 4 specimens can be changed at one time.
Specimen parking stage
Up to 12 specimens can be held.
Subject to technical changes; errors excepted. All brand names that appear in the text are registered trademarks of the manufacturers.
Professor at the Graduate School of Frontier Biosciences, Osaka University